3-BROMOANILINE: APPLICATIONS, PROPERTIES, AND INDUSTRIAL SIGNIFICANCE

3-Bromoaniline: Applications, Properties, and Industrial Significance

3-Bromoaniline: Applications, Properties, and Industrial Significance

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Introduction


3-Bromoaniline is an important intermediate compound in the field of organic synthesis, pharmaceutical development, and dye manufacturing. With its distinctive chemical structure and reactivity, it serves as a foundational building block for the production of various fine chemicals, agrochemicals, and active pharmaceutical ingredients (APIs).





Chemical Identity



  • IUPAC Name: 3-Bromoaniline

  • Other Names: Meta-Bromoaniline, m-Bromoaniline

  • Molecular Formula: C6H6BrN

  • Molecular Weight: 172.02 g/mol

  • CAS Number: 591-19-5

  • Appearance: Pale yellow to light brown liquid or solid

  • Solubility: Slightly soluble in water; soluble in organic solvents like ethanol, ether, and chloroform







Structure and Reactivity


3-Bromoaniline features a benzene ring substituted with a bromine atom at the meta-position and an amino group (-NH2). This structural arrangement allows it to participate in a variety of organic reactions, including:

  • Nucleophilic substitution

  • Electrophilic aromatic substitution

  • Coupling reactions (e.g., Suzuki, Heck, Buchwald-Hartwig)







Applications of 3-Bromoaniline


1. Pharmaceutical Intermediates


3-Bromoaniline is widely used in the synthesis of pharmaceutical compounds. It acts as a starting material or intermediate in the production of:

  • Analgesics

  • Anti-inflammatory agents

  • Antimicrobial drugs


2. Agrochemical Industry


It serves as a precursor in the manufacture of herbicides and pesticides, contributing to crop protection and agricultural productivity.

3. Dye and Pigment Manufacturing


3-Bromoaniline is also employed in the synthesis of azo dyes and pigments, where its amino group facilitates diazotization reactions.

4. Research and Development


It is a frequently used reagent in chemical research, particularly in the synthesis of heterocyclic compounds, molecular scaffolds, and catalysts.





Handling and Storage



  • Store in a cool, dry, and well-ventilated area

  • Keep container tightly closed and protected from light

  • Use appropriate PPE (gloves, goggles, lab coat) during handling

  • Avoid direct contact and inhalation; handle under a fume hood if necessary







Safety Information



  • Hazard Statements: Harmful if inhaled or absorbed through the skin; causes skin and eye irritation

  • Precautionary Measures: Use in a controlled environment with proper ventilation and protective equipment

  • Disposal: Must be disposed of according to local environmental regulations







Conclusion


3-Bromoaniline is a versatile aromatic amine widely used in pharmaceutical, agrochemical, and dye industries. Its reactivity and functional groups make it a valuable intermediate in the synthesis of complex molecules. With ongoing research and innovation, the demand for high-purity 3-Bromoaniline continues to grow across industries.

Looking to source 3-Bromoaniline? Contact us for bulk availability, COA, MSDS, and global shipping options.

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